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5.2 A Study on the effects of Hare Krishna Mantra Meditation 
...the maha mantra has potential for utilization in clinical areas... such as treatment of stress,depression, and addictions.
A 3-group study was conducted on the effects of chanting the Hare Krishna maha mantra on stress, depression, and the three modes of nature - sattva, rajas, and tamas - described in the Vedas as the basis for human psychology. Sixty-two subjects, self-selected through newspaper advertisements in a Southeastern university town,completed the study. Average age
was 24.63 years, with 31 males and 31 females participating. Stress was measured with the Index of Clinical Stress, depression was measured with the Generalized Contentment Scale, and
the modes of nature (or gunas), were measured with the Vedic Personality Inventory. Subjects were tested at pre-test, post-test, and follow-up, with testing times separated by four weeks. Participants were randomly assigned to a maha mantra group, an alternate mantra group, and a control group. Subjects in each of the chanting groups chanted their mantra approximately 25 minutes each day.
The researcher concocted a mantra as the alternate mantra, though subjects in the alternate group thought it was a genuine Vedic mantra. Primary hypotheses of the study were based on Vedic theory, and stated that the maha mantra group would increase sattva, and decrease stress, depression, rajas and tamas, significantly more than the other two groups. ANCOVA results, controlling for gender and age, supported these hypotheses at p < .05 for all dependent variables except rajas, with effect sizes (eta2) for the four variables whose results supported the hypothesis ranging from .21 to .33. The author suggests that the maha mantra has potential for utilization in clinical areas similar to those where other interventions of Eastern origin have been successful, such as treatment of stress, depression, and addictions.